66 A COMPUTATIONAL PHENOTYPE FOR CARBAPENEM-RESISTANT ENTEROBACTERALES AND EXTENDED-SPECTRUM BETA-LACTAMASE-PRODUCING ENTEROBACTERALES INFECTIONS TO SUPPORT ELECTRONIC HEALTH RECORD-BASED SURVEILLANCE EFFORTS

66 A computational phenotype for carbapenem-resistant Enterobacterales and extended-spectrum beta-lactamase-producing Enterobacterales infections to support electronic health record-based surveillance efforts

Objectives/Goals: The objective of this project was to develop electronic health record-based algorithms, or computational phenotypes, for carbapenem-resistant Enterobacterales (CRE) and extended-spectrum beta-lactamase-producing Enterobacterales (ESBL) infections based on public health surveillance case definitions.Methods/Study Population: We ana

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Microtubules oppose cortical actomyosin-driven membrane ingression during C. elegans meiosis I polar body extrusion.

During C.elegans oocyte meiosis I cytokinesis and polar body extrusion, cortical actomyosin is locally remodeled to assemble a contractile ring that forms within and remains part of a much larger and actively contractile cortical actomyosin network.This network both mediates contractile ring dynamics and generates shallow ingressions throughout the

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Genotoxic changes in peripheral lymphocytes after therapeutic exposure to crude coal tar and ultraviolet radiation

Aims: Goeckerman therapy is based on combined exposure to UV radiation (UVA, UVB) and crude coal tar (PAHs).Some indicators suggest a genotoxic hazard, however, the level of genotoxic risk of the therapy has not yet been investigated sufficiently.This study aims to assesss the genotoxic risk.Methods: The studied group consisted of patients with chr

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